Proteins
- The breast cancer susceptibility protein BRCA2The breast cancer susceptibility protein BRCA2, first identified in 1995, is a critical recombinase regulator that ensures genomic stability through high fidelity repair of double stranded breaks (DSB) and preventing stalled replication forks from replicatingin the DNA.
- The HAT (Half A TPR) repeat (from the Interpro site) has a repetitive pattern characterised by three aromatic residues with a conserved spacing. They are structurally and sequentially similar to TPRs (tetratricopeptide repeats). HAT-repeat-containing proteins appear to be components of macromolecular complexes that are required for RNA processing [PMID: 9478129]. The repeats may be involved in protein-protein interactions. The HAT motif has striking structural similarities to HEAT repeats (IPR000357), being of a similar length and consisting of two short helices connected by a loop domain, as in HEAT repeats.