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Lovastatin-lactone v. F420 in the A5UMI1 site.

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posted on 2016-04-08, 14:07 authored by Steven Muskal, Joe Sliman, John Kokai-Kun, Mark Pimentel, Vince Wacher, Klaus Gottlieb

The Lovastatin-lactone form is shown with green sticks, and F420 with red sticks. Residues within 5 angstroms of the ligands are labeled and highlighted. Hydrophilic site residues are shown in cyan, and hydrophobic residues in grey.

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Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway

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Keywords

IBS IBS-C Lovastatin homology modelling multi-site docking Biochemistry

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