Human SOD1 co-overexpressed in motor neurons and glial cells and treated with 3 mM BMAA.
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Shown are survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment (10 flies per vial). Panels A, B and C represent flies expressing mutant human A4V, G85R, wild type SOD1 proteins. The 50% survival rate of A4V, G85R, and hSOD1 when compared with dSOD1 is increased by 8, 30, and 15%, respectively. Differences were considered statistically significant if p