Human SOD1 over-expressed in glial cells enhances the effect of BMAA on reducing the longevity of flies.
Shown are survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment (10 flies per vial). Panels A, B, and C represent flies expressing mutant human A4V, G85R, wild type SOD1 proteins. The 50% survival rate of A4V, G85R, and hSOD1 when compared with dSOD1 is decreased by 31, 38, and 38%, respectively. Differences were considered statistically significant if p