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Effects of H2O2 on SOD1 transgenic flies.

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posted on 2012-11-29, 11:39 authored by Rafique Islam, Emily L. Kumimoto, Hong Bao, Bing Zhang

Five day-old male flies expressing SOD1 proteins in motor neurons (A), glial cells (B) and in motoneurons together with glial cells (C) were treated with 1% H2O2 diluted in 3% sucrose. The results indicate an enhancing effect of H2O2 on mutant SOD1 toxiciy in MNs or glia when compared to driver>UAS-dsod1, but not to driver>CS control. Statistical analysis was performed using a two-tailed ANOVA method in Prizm software and was considered significant if p